COPA and infection: The second most-reduced TIIE level was for COPI vesicle component COPA, with 45% TIIE compared to scrambled [Fig. 2; siRNA 1 = 0.5335 (P = 0.0006); siRNA 2 = 0.2524 (P = 0.0013); siRNA 3 = 0.5664 (P = 0.0029)], with these siRNAs proving effective for knockdown of the corresponding COPA target and also infection of the related Hazara nairovirus (33).