PTS and infection: In agreement with reports of SARS-CoV-2 tropism for PTs (15, 17, 19, 21, 25, 51, 52), virus was predominantly detected in PT segments [marked here with Lotus tetragonobulus lectin (LTL)], confirming PTs as a major target for infection and further validating the suitability of the enhanced organoid model for subsequent experiments (Fig. 1B).