After receiving tissue plasminogen activator (tPA) treatment, the symptoms of pathological damage in IS patients were effectively alleviated, accompanied by a significant increase in serum IL‐38 levels,121 which indicates that IL‐38 is negatively correlated with pathological damage after IS, and can be used as an early and reliable predictive marker for stroke prognosis. The gene discussed is IL1F10; the disease is stroke disorder.