Our results showed that Sev dramatically downregulated the FtH, FtL expression, and upregulated the TfR1 expression in hippocampus and/or cortex, indicating that Sev also caused the iron deficiency in the cortex and hippocampus as shown in Figure 4A–D which was consistent with Perl's iron‐staining results (Figure 4E,F). The gene discussed is TFRC; the disease is Iron deficiency anemia.