MBP and Cognitive impairment: Interestingly, our results showed that these damage effects (including MWM, the expression of proteins related to iron metabolism, MBP expression, cell proliferation, and the number of neurons) induced by Sev could be significantly eliminated by iron supplementation pretreatment, indicating that iron therapy could rescue the cognitive impairment, hypomyelination, and inhibition of cell proliferation of NSCs/NPCs induced by Sev, as shown in Figures 7, 8, 9.