FTL and nutritional disorder: Our results showed that Sev similarly upregulated the expression of TfR1 (t(4) = 11.78, p < 0.001), downregulated the expression of FtH (t(4)=4.410, p = 0.0116) and FtL (t(4) = 3.199, p = 0.0329), when the NE4C cells were treated with Sev for 6 h as shown in Figure 6A,B, indicating that Sev also induced the iron deficiency in NE4C cells.