To determine whether CTRPs increased the diagnostic efficacy of conventional factors for AD, all aforementioned variables (age, sex, years of education, APOE4‐positive, BMI, TG, and HDL‐C) were used to establish the basic model for AD diagnosis, namely Model 0 where AUC of the ROC curve was greater than the random probability AUC (AUC = 0.825, p < 0.001). Here, APOE is linked to Alzheimer disease.