Compared with the CN group, the proportion of APOE4‐positive (17.14 vs. 42.34, p < 0.0001) was increased in the AD group, while years of education (9 (8–12) vs. 6 (5.5–9), p < 0.0001), BMI (23.86 ± 3.52 vs. 21.35 ± 3.15, p < 0.0001), TG (1.78 ± 1.36 vs. 1.30 ± 0.51, p = 0.0106), and HDL‐C (1.63 ± 0.47 vs. 1.42 ± 0.41, p < 0.0001) were reduced (Table 1). The gene discussed is APOE; the disease is Alzheimer disease.