C1QTNF3 and Alzheimer disease: Given that cognitive impairment is the core symptom, and neuroinflammation, neuronal loss, and synaptic degeneration are pathological features of AD, we designed a retrospective study, established both AD and cognitively normal (CN) control groups, explored relationships of plasma CTRP3, 4, and 14 with the presence, main clinical characteristics, and current representative blood biomarkers of AD, and investigated their performances in the diagnosis of this disease.