It was also of statistical significance in CTRP4's correlations with pT217 (rs = 0.222, p = 0.040) in female AD patients, and pT181 (rs = 0.270, p = 0.040) and NfL (rs = 0.274, p = 0.037) in APOE4‐positive AD patients (Figure 2J–L). This evidence concerns the gene APOE and Alzheimer disease.