Last but not the least, the immunofluorescence detection indicated that the co‐localization of HDAC6 and α‐tubulin was suppressed after downregulation of HTRA1 in GBM cells, and overexpression of HTRA1 enhanced the HDAC6/α‐tubulin co‐localization (Figure 6G). The gene discussed is HTRA1; the disease is glioblastoma.