ACHE and Alzheimer disease: The particulararchitecture and amino acid composition of the AChEgorge, with a deep and narrow cavity, far from hampering its physiologicalfunctioning, make AChE highly efficient machinery to hydrolyze ACh.In diseases that occur with a cholinergic deficit, such as AD, theAChE gorge offers plenty of opportunities to design drug candidatesthat block that machinery and ameliorate cholinergic neurotransmission.