ACHE and Alzheimer disease: We also discuss howthe molecular template provided by AChE enables the design of compoundsthat fit well within other key proteins in AD, such as BACE-1 andamyloidogenic proteins, and how it can be used to rationally designAChE inhibitor-based multitarget agents that modulate key pathogenicevents of AD, such as oxidative stress and neuroinflammation.