BRCA2 and ovarian carcinoma: There were 1121 and 1275 female first-degree family members in BRCA1 and BRCA2 families, respectively, of whom 144 and 65 family members in BRCA1 families were diagnosed with breast and ovarian cancer, respectively, and the corresponding number in BRCA2 families were 152 and 19 (eTable 4).