This study aimed to study the effects of the aqueous extract of S. mirzayanii leaves on the expression level of glucose transporter-4 (GLUT4), phosphoenolpyruvate carboxykinase (PEPCK), and glucose 6-phosphatase (G6Pase) genes in streptozotocin (STZ)-induced diabetes in rat models. Here, G6PC1 is linked to diabetes mellitus.