A bibliographic search was done using the following databases: PubMed, Scopus, Web of Science, and Google Scholar to identify studies and papers published in English using the following keywords: ‘ischemic stroke’, ‘stroke’, ‘myocardial infarction’, ‘cerebral ischemia’, ‘heart ischemia’, ‘peripheral vascular disease’, ‘peripheral ischemia’, ‘renal ischemia’, ‘retinal ischemia’, ‘lung ischemia’ in combination with ‘TRPA1’. The gene discussed is TRPA1; the disease is ischemic stroke.