A bibliographic search was done using the following databases: PubMed, Scopus, Web of Science, and Google Scholar to identify studies and papers published in English using the following keywords: ‘ischemic stroke’, ‘stroke’, ‘myocardial infarction’, ‘cerebral ischemia’, ‘heart ischemia’, ‘peripheral vascular disease’, ‘peripheral ischemia’, ‘renal ischemia’, ‘retinal ischemia’, ‘lung ischemia’ in combination with ‘TRPA1’. This evidence concerns the gene TRPA1 and Cerebral ischemia.