TNF and cancer: Figure 6A shows that THRAP3 was predicted to be a positive regulator of cell cycle, cell growth, vacuole, lysosome, centrosome. In addition, THRAP3 is involved in regulating alpha-beta T cell differentiation. THRAP3 expression is positively connected with cancer-related pathways, including MAPK, PI3K-Akt, Hippo, calcium, Rap1, cAMP, TNF, p53, HIF-1, hedgehog pathways (Figure 6B).