Cholesterol-induced suppression of Kir currents was also observed in endothelial cells freshly-isolated from hypercholestreolemic animal models, diet-induced hypercholesterolemia in pigs (Fang et al., 2006) and genetically-induced hypercholesterolemia in ApoE−/− mice (Fancher et al., 2018). Here, APOE is linked to familial hypercholesterolemia.