A study reported that EVs derived from GC induced M2 polarization of macrophages through the STAT3 pathway; M2-polarized macrophages secrete IL-6 to promote the migration of GC cells, leading to peritoneal metastasis of GC, but the cargoes that play a key role in these EVs are still unclear (Ito et al., 2021). The gene discussed is IL6; the disease is gastric cancer.