EVs secreted by p53-deficient BM-MSCs can transport ubiquitin protein ligase E3 component n-recognin 2 to GC cells and p53 wild-type BM-MSCs, to reprogram cells in the TME and promote GC metastasis by activating the Wnt/β-catenin pathway, but its underlying mechanisms have not been elucidated yet (Mao et al., 2017). The gene discussed is TP53; the disease is gastric cancer.