DUSP2 and gastric cancer: In the study by Qiu et al., miR-519a-3p from GC-derived EVs was found to accumulate mainly in the liver, and EVs enriched with miR-519a-3p stimulated the MAPK/ERK pathway by targeting DUSP2, leading to M2 polarization of macrophages; M2 polarized macrophages accelerated liver metastasis of GC by promoting the formation of pre-metastatic niches and by inducing angiogenesis in the liver.