Zhang et al. reported that EVs derived from GC cells induced N2 polarization of neutrophils by the HMGB1/TLR4/NF-κB signaling pathway, promoting autophagy and tumor activation, and N2-polarized neutrophils, in turn, promoted the metastasis of GC (Zhang et al., 2018a). This evidence concerns the gene HMGB1 and neoplasm.