CDH2 and gastric cancer: Xia et al. reported that in the hypoxic TME, hypoxia-inducible factors 1α increased the release of miR-301a-3p from GC-derived EVs, and treatment of GC cells with these EVs resulted in upregulation of mesenchymal cell markers (N-cadherin and vimentin) and downregulation of epithelial cell markers (E-cadherin), indicating that these EVs promoted tumor metastasis by inducing EMT in GC cells (Xia et al., 2020).