The LGMD neurons are first discovered in locust by O'Shea and Williams (1974), and has been tested, As illustrated in Figure 1A, the LGMD neurons are composed of two neighboring neurons: LGMD1 and LGMD2, both of which contain extensive dendrite trees with fan-like shapes within their pre-synaptic regions. The gene discussed is CAPN3; the disease is limb-girdle muscular dystrophy.