However, unlike LPS/ATP, the inflammatory molecular switch RIP3 was not involved in the activation of NLRP3 inflammatory vesicles in murine Chlamydia-stimulated BMDM, suggesting that chlamydial infection leads to caspase-1 cleavage and IL-1β release by a different mechanism than LPS/ATP (61). The gene discussed is IL1B; the disease is chlamydia trachomatis infectious disease.