BDNF and glaucoma: The 70% of glaucoma cases are caused by elevated IOP, but it is clear that different molecular mechanisms are involved, such as oxidative stress, glutamate toxicity, neurotrophin deprivation, mitochondrial dysfunction, ischemia/hypoxia processes, protein misfolding, autoimmunity, dysfunction of autophagy processes, vascular dysregulation or neuroinflammation, which may also be responsible for RGC degeneration and death in cases of non-elevated IOP (Chang and Goldberg, 2012; Ramirez et al., 2017; Toft-Kehler et al., 2017; Duarte, 2021; Gutteridge, 2021).