The onset of the inflammatory process in glaucoma is triggered by impaired communication between RGCs and glial cells, inducing the release of proinflammatory mediators, such as ROS, NO, TNF-α, and IL-1β (Nakazawa et al., 2006b; Luo et al., 2010; Chua et al., 2012; Tezel et al., 2012; Madeira et al., 2015). This evidence concerns the gene TNF and glaucoma.