In the optic nerve of patients with glaucoma, elevated levels of both TNF-α and Fas ligand (FasL), a protein with proapoptotic capacity, are observed, and both are linked to the pathogenesis of glaucoma (Yan et al., 2000; Tezel et al., 2001; Sawada et al., 2010; Gregory et al., 2011). The gene discussed is FASLG; the disease is glaucoma.