In glaucoma, reactive microglial cells initially phagocytize the debris of damaged or dead RGCs, contributing to the maintenance of a toxin-free microenvironment, and also release neurotrophic factors such as BDNF or CNTF, providing neuroprotection and promoting tissue neuroregeneration (Silverman and Wong, 2018; Alqawlaq et al., 2019). This evidence concerns the gene BDNF and glaucoma.