The protooncogene c-MYC is overexpressed in the most malignant primary brain tumor, glioblastoma multiforme (GBM), and is considered essential for GB transformation by either increasing the sensitivity of astrocytes to gliomagenesis (Lassman et al., 2004) or influencing the brain tumor microenvironment by boosting the expression of inflammatory mediators such as IL-1β (Shchors et al., 2006). The gene discussed is MYC; the disease is brain neoplasm.