Alcohol consumption in males has previously been shown to decrease leptin levels (Röjdmark et al., 2001; Otaka et al., 2007), and leptin has been suggested to be involved in both the formation of alcoholic fatty liver disease (Tan et al., 2012) as well as craving/relapse (Aguiar-Nemer et al., 2013; Haass-Koffler et al., 2015). Here, LEP is linked to alcoholic fatty liver disease.