These findings were highly suggestive of the presence of specific autoantigens in IgG4-RD and indeed were followed by the discovery of the autoantigens annexin A11, laminin 511-E8, galectin-3, and prohibitin 1 in people with IgG4-RD (10–13). Here, LGALS3 is linked to immunoglobulin G4-related sclerosing disease.