LGALS3 and immunoglobulin G4-related sclerosing disease: Notably, in the clinically diverse galectin-3 IgG4-RD cohort, only 15% of the people who were positive for galectin-3 autoantibodies had a history of IRC, indicating that galectin-3 positivity in IgG4-RD does not de facto lead to the development of IRC.