PHB1 and primary biliary cholangitis: We hypothesized that prohibitins—in analogy with the IRC autoantigens annexin A11 and laminin 511-E8 and consideration of a potential pathogenetic role of prohibitin 1 in PBC (30)—could contribute to the protection of human cholangiocytes against toxic bile acid influx and stabilization of the biliary bicarbonate umbrella.