The performance of I°I candidate signatures: ADM+CD177+FAM20A+ITGA7+MPP9+OLAH, ADM+FAM20A+OLAH and FAM20A+OLAH were compared on a wider cohort of samples, five independent, previously published, adult datasets were selected (four Sepsis datasets: GSE154918, GSE131761, GSE28750, GSE65682 and a COVID-19 study which contained a bacterial infection group: GSE16173. This evidence concerns the gene ADM and bacterial infectious disease.