Although, all signatures depicted achieved an AUC of 1.0, variation in separation between controls and SIRS/sepsis groups and cut-offs is visible within the panels with the largest combination of biomarkers i.e. (D) ADM+CD177+FAM20A+ITGA7+MPP9+OLAH showing smallest differences between control and disease groups. The gene discussed is CD177; the disease is systemic inflammatory response syndrome.