Promoted genomic and non-genomic pathways and angiogenesis;ERalpha mediated mechanism of immune evasion (see Table 1A, BCCs);upregulation of transcription and secreted levels of TNFalpha in ER positive BCCs (autocrine positive feedback loop);ER-alpha expression and modulation in stromal cells;induction of Th2 response and M2 polarization (see Tables 1B, CD4+ Tcells and Table 1A, TAMs respectively) with related cytokine production; expansion of Tregs, MDSCs and APCs induced-inhibitory activity, increased tumor cell PD-L1 expression(see Table 1B, Tregs, MDSCs and APCs respectively). This evidence concerns the gene CD4 and neoplasm.