IL-6, TGF-beta, TNF-alpha, NF-kB, COX-2 and PGE-2 are pro-inflammatory cytokines present in the TME of ER+ breast cancer that are capable to activate pro-tumoral pathways mediating proliferation, immune evasion and metastasis (16, 84). The gene discussed is NFKB1; the disease is breast carcinoma.