The results revealed that B cell naïve, Monocytes, Macrophages M0, and Eosinophils were more abundant in sepsis cluster 1 (P<0.05), while B cell memory, T cells CD8, T cells CD4 memory resting, and Macrophages M2 were more abundant in sepsis cluster 2 (P<0.05). Here, CD8A is linked to Sepsis.