In this study, we investigated whether the serum levels of nine analytes, IL-6, IL-10, IFN-γ, NGAL, MMP-9, S100A8/A9, S100B, TNF-α, and TWEAK, differed between patients with and without CI from a large, well-characterized SLE cohort. This evidence concerns the gene S100B and systemic lupus erythematosus.