Laryngeal edema is associated with bradykinin-dependent disorders such as hereditary angioedema (HAE) (primarily due to C1 inhibitor deficiency) or angioedema due to inhibition of angiotensin converting enzyme (ACE), while chronic spontaneous urticaria with or without accompanying angioedema is not associated with laryngeal edema (21, 22). The gene discussed is ACE; the disease is angioedema.