GADD45A and amyotrophic lateral sclerosis: Clinical observations indicate that in induced pluripotent stem cell (iPSC) lines differentiated into motor neurons from C9ORF72 ALS patients, there is an elevation in the levels of DNA damage markers γH2AX, ATR, GADD45α, and p53 in response to oxidative stress (Lopez-Gonzalez et al., 2016).