This review provided additional insights into the limited research findings on GADD45 family, particularly focusing on the expression and mechanism of action of GADD45α and GADD45γ in neurological disorders, and further explored the correlation between the GADD45 family and less-studied or even unstudied conditions such as PTSD and ADD, thereby addressing knowledge gaps concerning the involvement of the GADD45 family in central nervous system disorders. This evidence concerns the gene GADD45G and central nervous system disorder.