MAPT and frontotemporal dementia: In the comparison between FTD and SMC_CTR, the ability of Aβ42, Tau, and pTau to predict the diagnostic groups shows a significant improvement when proNGF is included as predictor in the diagnostic model, as witnessed by the significant difference between the two ROC curves (De Long’s test, p = 0.00032) and by the increased AUC (AUC = 0.790 for diagnostic model ∼ Aβ42 + Tau + pTau; vs. AUC = 0.895 for diagnostic model ∼ Aβ42 + Tau + pTau + proNGF) (Figure 3).