The box plots showed top five significant differences genes with significant differences between central and peripheral tumours in LumA, those were baculoviral IAP repeat containing 5 (BIRC5) (t = −7.59, p = .0001), Cyclin E1 (CCNE1) (t = −6.28, p = .0002), thymidylate synthetase (TYMS) (t = −5.08, p = .0009), interleukin 4 receptor (IL4R) (t = −4.93, p = .001) and marker of proliferation Ki‐67 (MKI67) (t = −4.70, p = .001) (Figure 4A). Here, TYMS is linked to neoplasm.