The top five significant different genes with significant differences between central and peripheral tumours in LumB were MIS18 binding protein 1A (MIS18A) (t = −4.56, p = .0004), WNT inhibitory factor 1 (WIF1) (t = −4.22, p = .0008), checkpoint kinase 2 (CHEK2) (t = −4.20, p = .0008), endomucin (EMCN) (t = −3.93, p = .001) and cyclin‐dependent kinase 4 (CDK4) (t = −3.88, p = .001) (Figure 4B). This evidence concerns the gene CHEK2 and neoplasm.