Given the crucial function of APNG on regulating chemo‐resistance of SNB19 and SF295 cells, and MGMT was not involved in these (Figure S1B), the relevance between dramatic alteration of APNG in response to ALKBH7 and glioblastoma chemo‐resistance was further investigated, which disclosed that expression of ALKBH7 in SNB19 and SF295 cells increased after co‐culturing with TAAs (Figure 6A). This evidence concerns the gene MPG and glioblastoma.