TAAs have been reported to express specific markers, such as TGF‐β and CD44 enhancing glioblastoma invasion, as well as upregulation of CD274 and tenascin‐C to promote the formation of immune suppressive TME,29, 30, 31 indicating the great pro‐tumor potential of TAAs, which derived from transformation of naive astrocytes. Here, CD274 is linked to neoplasm.