TAAs had a high level of ALKBH7 expression, and TAAs‐derived secretory ALKBH7 can induce upregulation of APNG in glioblastoma cells, suggesting the role of ALKBH7 mediating on APNG upregulation during crosstalk between TAAs and glioblastoma cells to promote TMZ resistance. The gene discussed is MPG; the disease is glioblastoma.