Since the mutual regulatory relationship existed between ALKBH7 derived from TAAs and APNG expression in glioblastoma cells, which contributed to chemo‐resistance of glioblastoma, targeting ALKBH7 can repress APNG expression and help further increase the antitumor effect of TMZ, which has been verified in the current studies. The gene discussed is ALKBH7; the disease is glioblastoma.