In this study, we identified 12 shared genes (EPHA3, RASIP1, PENK, LRRC17, CEBPB, EFEMP2, UBAP1, PPP1R15A, SPEN, MAFF, GADD45B and KLF4) and investigated the underlying comorbidity mechanism between T2DM and OA. The gene discussed is RASIP1; the disease is type 2 diabetes mellitus.