FGF19 and portal hypertension: Interestingly, the ratio between FGF19 and BA levels was significantly lower in patients with severe portal hypertension (HVPG ≥ 16 mmHg: 4.92 [2.13–8.79] vs. HVPG  < 16 mmHg: 12.8 [8.90–21.8], p < 0.001) and dACLD (dACLD: 5.82 [2.84–11.7] vs. cACLD: 14.0 [7.81–21.8], p < 0.001), suggesting a relative increase of BA levels as compared to systemic FGF19 levels in patients with severe portal hypertension or dACLD (Supplementary figure S4).