In addition, study by Van et al. showed that compared with CK19 negative hepatocellular adenoma, CK19 positive HCC significantly expressed higher glypican-3, B-cell specific murine leukemia virus integration site 1, adhesion proteins, integrin beta-1/CD29, and prominin-1/CD13346. This evidence concerns the gene ITGB1 and hepatocellular carcinoma.