Interestingly, β-catenin was identified in our mass-spec analysis, suggesting that LINC00313 may somehow interact with β-catenin and modulate the activity of target genes, including TCF7. Nevertheless, our study highlights an important and new role for LINC00313 as a modulator of Wnt/TCF signalling, that affects tumour progression and has clinical implications in CCA. The gene discussed is TCF7; the disease is cholangiocarcinoma.