MACO1 and disorder of ear: For the cluster predominated by ear diseases, five independent SNPs (e.g., rs113248357, rs193072412, rs556283981), 183 mapped genes (e.g., RHCE, TMEM57, LDLRAP1), and two biological pathways (i.e., R-HSA-3700989 Transcriptional Regulation by TP53, R-HSA-1475029 Reversible hydration of carbon dioxide) were identified in both.