Regarding the most important parameters from baseline clinical and angiographic characteristics for 5-year of follow-up: for age < 65 years, female, diabetes and diabetes requiring insulin, reduced EF, non-STEMI, LM disease and increased SYNTAX score surgery was associated with improved prognosis (P < 0.01 for Odds Ratios), while PCI was better for frailty patients, with COPD and severe PH, after previous revascularization, MI and stroke/TIA, with STEMI, PAD, carotid stenosis, bifurcation and severe calcification (P < 0.01 for Odds Ratio). The gene discussed is INS; the disease is chronic obstructive pulmonary disease.