Our analysis revealed that (irrespectively of final treatment strategies—CABG + OMT or PCI + OMT): age, frailty, diabetes requiring insulin, COPD, severe PH, NYHA class III-IV, CKD, anemia, cardiogenic shock on admission, PAD, active cancer, EuroSCORE II, LM disease, number of lesion and SYNTAX score were independently associated with increased occurrence of overall mortality in long-term follow-up P < 0.01 for all). The gene discussed is INS; the disease is peripheral arterial disease.