In line with our results that knockdown of Vcam1 in MC38-mCherry tumor cells enhanced iNKT cell infiltration into tumors (Fig. 4g) and augmented their IFN-γ production (Fig. 4o), knockdown of tumor Vcam1 further enhanced anti-tumor efficacy of iNKT cells (Fig. 8a–d). Here, VCAM1 is linked to neoplasm.