With data in TCGA, we found that low grade gliomas (LGG) patients with higher tumor VCAM1 expression exhibited lower survival rates (Fig. 7a), and VCAM1 level was negatively correlated with level of iNKT cell signature genes, ZBTB16 and TRAV24, indicating poor iNKT cell infiltration in VCAM1 high expression LGG patients (Fig. 7b). This evidence concerns the gene ZBTB16 and central nervous system cancer.