The GSK3β polymorphisms are associated with the high risk of MDD in Chinese Han Population.61 In our recent reports, the activation of GSK3β is also increased in the sorted astrocytes from the MDD-related stress-treated mice model and MDD clinic patients’ plasma.62 In addition, after fluoxetine-mediated stimulation of the 5-HT2B receptor in astrocytes, epidermal growth factor receptor (EGFR) is transactivated and subsequently activates the MAPK/ERK and PI3K/AKT signaling cascades, which control the expression of mRNA or proteins that may be linked to mood disorders, such as SERT. This evidence concerns the gene SLC6A4 and major depressive disorder.