In addition, it has been observed that stimulating NLRP3 inflammasome assembly can induce depression-like behaviors in rodents exposed to LPS or CUMS.156,157 Research on the effect of astrocyte-specific NLRP3 knockout suggests that the astrocytic NLRP3 inflammasome exerts a significant effect on astrocytic pyroptosis via the Casp-1/GSDMD pathway in depression.156,157 Therefore, efficient NLRP3 inflammasome inhibitors are novel therapeutic agents for MDD. This evidence concerns the gene CASP1 and major depressive disorder.