To address the role of CUL4B in neurodevelopment, we employed two iPSC lines previously generated by our group from peripheral blood mononuclear cells (PBMCs) of two independent XLID patients (SDUBMSI002-A cell line and SDQLCHi015-A cell line) [20, 21]. This evidence concerns the gene CUL4B and cask-related x-linked intellectual disability.