Of the SNPs examined, only the SNP increasing CHRNA5 expression had a significant association with AD neuropathology, with the A allele of the regulatory-SNP rs1979905 significantly negatively associated with β-amyloid load after false discovery rate (FDR) correction for multiple comparisons (t = −2.81, pFDR = 0.015, corrected for 36 models per [47]). Here, CHRNA5 is linked to Alzheimer disease.