NFATC3 and cardiac hypertrophy: Through RNA-seq high-through sequencing, biogenic analysis, and experimental studies, they found that ECHS1 defects enhanced histone H3K18cr and H2BK12cr modifications, promoted the recruitment of NFATC3 transcription factors on the promoter of myocardial hypertrophy gene, and promoted the occurrence of myocardial hypertrophy and cardiac remodeling [49].