THOC2 and Anxiety: As the mouse model is based on a THOC2 pathogenic NDD variant, we subjected eight-week-old Thoc2Δ/Y mice and Thoc2+/Y littermates to a battery of neurobehavioral tests to assess cognition, motor coordination, sensorimotor function, gross and fine motor skill, and anxiety-like behaviour (Fig. 2 and Supplementary Fig. 2).