THOC2 and Intellectual disability: We utilized one such hypomorphic THOC2 variant (NC_000023.11:g.123609724_123612089del, ClinVar: VCV000804360.1) we reported in a patient with intellectual disability (ID), speech problems, short stature, low body weight, sensorineural hearing loss and microcephaly5 to generate a mouse model with a microdeletion encompassing Exons 37 and 38.