Functional enrichment analysis of the UPP1high tumor cell population demonstrated these cells were related to cancer-related biological processes, including Tumor_Invasiveness, PI3K/AKT/mTOR_signaling_pathway, MYC_targets, MAPK_signaling_pathway, as well as TGFβ_signaling_pathway. The gene discussed is TGFB1; the disease is neoplasm.