In the groups with high SHMT2 and MTHFD2 expression, there were more cases of larger tumor sizes and distant metastasis (Fig. 2f, g and Supplementary Table 1-2), whereas no significant difference was observed between the TDS-high and TDS-low groups (Fig. 2f, g and Supplementary Table 3). This evidence concerns the gene MTHFD2 and neoplasm.