CD73 upregulates SOX9 through the AKT/c-MYC signaling pathway and impedes its ubiquitination and subsequent degradation via inhibiting GSK3β, thus promoting dedifferentiation and maintaining the stemness of HCC [111].Recently, Chen et al. established a hereditary GC model expressing both SOX2 and SOX9, with distinctive cell populations and metastasis in the liver and peritoneum. This evidence concerns the gene AKT1 and hepatocellular carcinoma.