In a melanoma model, it was demonstrated that while Lymphocyte function-associated molecule-1 (LFA-1) is involved in the initial capture of neutrophils, the interaction between ICAM-1 expressed on tumor cells and Mac-1 expressed on neutrophils is, on the other hand, more involved in maintaining clusters, particularly when stimulated with inflammatory cytokines [34]. Here, ITGB2 is linked to neoplasm.