Second, we deleted mono/macrophages and found that deletion of macrophages with anti-CSF1R Ab or clodronate liposomes (CL) ablated the inhibitory effect of anti-C5aR1 Ab on MC-38 colorectal cancer growth in parallel with a decrease in the infiltrated CD8+ T cells (Fig. 1L–M and Supplementary Fig. 1D–F). Here, CD8A is linked to colorectal cancer.