To further explore the effects of C5aR1 inhibition on reprogramming TAMs, we examined the infiltrated immune cells and found that compared with wild-type (WT, C5ar1+/+) mice and isotype antibody (Ab) treated mice, both C5ar1 deletion and C5aR1 inhibition reduced tumor size and tumor weight along with an increase in the percentage of infiltrated CD8+ T cells and the number of CD8+IFN-γ+ cells (Fig. 1A–D). This evidence concerns the gene C5AR1 and neoplasm.