TNF and irritable bowel syndrome: Moreover, transient receptor potential melastatin 8 (TRPM8) receptor is highly expressed in the dendritic cells of the colonic tissue of IBS patients compared with healthy controls and specific stimulation of TRPM8 receptor causes reduction of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α release from the biopsy specimens of IBS patients [24].