Yet, CD70-CAR-IL-15 NK cells were significantly more competent than CD70-CAR NK cells in completely eradicating CD70+ PDAC and CRC CAFs (RLT-PSC24h: 13.3 ± 1.5% vs 66.2 ± 5.2%, hPSC2124h: 16.9 ± 1.2% vs 45.9 ± 3.6%, CT5.3hTERT24h: 16.7 ± 1.6% vs 58.7 ± 10.2%, respectively; Fig. 5D). Here, IL15 is linked to colorectal carcinoma.