Therefore, CD70+ immortalized CAF cell lines, derived from PDAC patients (i.e., RLT-PSC and hPSC21) and a CRC patient (i.e., CT5.3hTERT; Fig. 5A, B, C) were co-cultured with CD70-CAR NK cells, CD70-CAR-IL-15 NK cells, or MOCK control NK cells, and longitudinal CAF cell survival was monitored using the xCELLigence RTCA system. The gene discussed is CD70; the disease is colorectal carcinoma.