In the gender-stratified analysis, there was evidence for significant interaction of alcohol intake with ADH1B rs1229984 for association with serum urate level and hyperuricaemia among both men (P = 1.1 × 10−17 and P = 4.3 × 10−9, respectively) and women (P = 1.4 × 10−26 and P = 1.1 × 10−6, respectively). The gene discussed is ADH1B; the disease is hyperuricemia.