CD4 and colorectal carcinoma: In the group of overweight CRC patients, f__Ruminococcaceae.g__Clostridium_IV showed significant positive correlation with T cells regulatory and Macrophages M2, g__Bacteroides.s__Bacteroides_stercoris showed significant negative correlation with NK cells activated, and f__Ruminococcaceae.g__Clostridium_IV was significantly negatively correlated with Dendritic cells activated and T cells CD4 memory activated (Fig. 4C, D).