CD163 and lobular neoplasia: Although the proportion of M2-like macrophages expressing CD163 and/or CD206 is also significantly higher than the proportion of M1-like macrophages in kidneys from most pediatric LN patients (ISN/RPN classes II, III, and V), M1-like macrophages were significantly higher in pediatric LN than in kidneys from adult patients with LN and even the dominant subpopulation in ISN/RPN class IV.